• Western blot analysis of lysates from HepG2 cells treated with Na3VO4 0.3mM 40', using PLCG2 (Phospho-Tyr753) Antibody. The lane on the right is blocked with the phospho peptide.
  • Immunohistochemical analysis of paraffin-embedded Human colon cancer. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using PLCG2 (Phospho-Tyr753) Antibody. The picture on the right is blocked with the phospho peptide.
  • Western blot analysis of various cells using Phospho-PLC Gamma 2 (Y753) Polyclonal Antibody

Anti-Phospho-PLCG2-Tyr753 antibody (721-770 aa) (STJ90768)

SKU:
STJ90768

€57.50 - €282.50
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-2-Tyr753 (721-770 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PLCG2
Gene ID: 5336
Uniprot ID: PLCG2_HUMAN
Immunogen Region: 721-770 aa
Specificity: Phospho-PLC Gamma 2 (Y753) Polyclonal Antibody detects endogenous levels of PLC Gamma 2 protein only when phosphorylated at Y753.
Immunogen: The antiserum was produced against synthesized peptide derived from the human PLCG2 around the phosphorylation site of Tyr753 at the amino acid range 721-770
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Protein Name 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-2
Phosphoinositide Phospholipase C-Gamma-2
Phospholipase C-Iv
Plc-Iv
Phospholipase C-Gamma-2
Plc-Gamma-2
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-166016
Reactome: R-HSA-1855204
Reactome: R-HSA-202433
Reactome: R-HSA-2029485
Reactome: R-HSA-2424491
Reactome: R-HSA-2871796
Reactome: R-HSA-2871809
Reactome: R-HSA-5607764
Reactome: R-HSA-5621480
Reactome: R-HSA-9027277
Reactome: R-HSA-9664323
Reactome: R-HSA-9679191
Reactome: R-HSA-9680350
Reactome: R-HSA-983695
Cellular Localisation Membrane Raft
Alternative Antibody Names Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-2 antibody
Anti-Phosphoinositide Phospholipase C-Gamma-2 antibody
Anti-Phospholipase C-Iv antibody
Anti-Plc-Iv antibody
Anti-Phospholipase C-Gamma-2 antibody
Anti-Plc-Gamma-2 antibody
Anti-PLCG2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance