||Rabbit monoclonal anti-Phospho-GYS1-S641 antibody is suitable for use in Western Blot.
||FOR RESEARCH USE ONLY (RUO).
||PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
||Store at-20°C. Avoid freeze/thaw cycles.
||A phospho specific peptide corresponding to residues surrounding S641 of human GYS1
| Post Translational Modifications || Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Phosphorylated at Ser-641 by DYRK2, leading to inactivation. Phosphorylated at Ser-641 by PASK, leading to inactivation.phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme. |
| Function || Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. |
| Protein Name || Glycogen Starch Synthase - Muscle |
| Database Links || Reactome: R-HSA-3322077Reactome: R-HSA-3785653Reactome: R-HSA-3814836Reactome: R-HSA-3828062 |
| Alternative Antibody Names || Anti-Glycogen Starch Synthase - Muscle antibodyAnti-GYS1 antibodyAnti-GYS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance