• Human cerebellum stained with anti-PGP 9.5 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staning of neurons.

Anti-PGP9.5 antibody [ZM160] (STJ180368)

SKU:
STJ180368

Current Stock:
Host: Mouse
Applications: IHC-p
Reactivity: Human
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Mouse monoclonal antibody Anti-PGP9.5 is suitable for use in Immunohistochemistry.
Clonality: Monoclonal
Clone ID: ZM160
Conjugation: Unconjugated
Isotype: IgG1 Kappa
Formulation: Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
Dilution Range: 1:100‐200
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: UCHL1
Gene ID: 7345
Uniprot ID: UCHL1_HUMAN
Specificity: Positive control tissue: Human brain.
Immunogen: Recombinant human UCHL1 protein
Tissue Specificity Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.
Post Translational Modifications O-glycosylated.
Function Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
Protein Name Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1
Uch-L1
Neuron Cytoplasmic Protein 9.5
Pgp 9.5
Pgp9.5
Ubiquitin Thioesterase L1
Database Links Reactome: R-HSA-5689603
Cellular Localisation Cytoplasm
Endoplasmic Reticulum Membrane
Lipid-Anchor
About 30% Of Total Uchl1 Is Associated With Membranes In Brain
Alternative Antibody Names Anti-Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 antibody
Anti-Uch-L1 antibody
Anti-Neuron Cytoplasmic Protein 9.5 antibody
Anti-Pgp 9.5 antibody
Anti-Pgp9.5 antibody
Anti-Ubiquitin Thioesterase L1 antibody
Anti-UCHL1 antibody

Information sourced from Uniprot.org

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