||FOR RESEARCH USE ONLY (RUO).
||Mouse monoclonal antibody Anti-PGP9.5 is suitable for use in Immunohistochemistry.
||Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
||Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
||Positive control tissue: Human brain.
||Recombinant human UCHL1 protein
| Tissue Specificity || Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. |
| Post Translational Modifications || O-glycosylated. |
| Function || Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. |
| Protein Name || Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1Uch-L1Neuron Cytoplasmic Protein 9.5Pgp 9.5Pgp9.5Ubiquitin Thioesterase L1 |
| Database Links || Reactome: R-HSA-5689603 |
| Cellular Localisation || CytoplasmEndoplasmic Reticulum MembraneLipid-AnchorAbout 30% Of Total Uchl1 Is Associated With Membranes In Brain |
| Alternative Antibody Names || Anti-Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 antibodyAnti-Uch-L1 antibodyAnti-Neuron Cytoplasmic Protein 9.5 antibodyAnti-Pgp 9.5 antibodyAnti-Pgp9.5 antibodyAnti-Ubiquitin Thioesterase L1 antibodyAnti-UCHL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance