||WB, IHC, IF
||Human, Mouse, Rat
||FOR RESEARCH USE ONLY (RUO).
||Rabbit monoclonal antibody anti-PGP9.5 is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence.
||PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
||WB 1:500-1:2000IHC 1:50-1:200IF 1:50-1:200
||Store at-20°C. Avoid freeze/thaw cycles.
||A synthesized peptide derived from human PGP9.5
| Tissue Specificity || Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. |
| Post Translational Modifications || O-glycosylated. |
| Function || Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. |
| Protein Name || Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1Uch-L1Neuron Cytoplasmic Protein 9.5Pgp 9.5Pgp9.5Ubiquitin Thioesterase L1 |
| Database Links || Reactome: R-HSA-5689603 |
| Cellular Localisation || CytoplasmEndoplasmic Reticulum MembraneLipid-AnchorAbout 30% Of Total Uchl1 Is Associated With Membranes In Brain |
| Alternative Antibody Names || Anti-Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 antibodyAnti-Uch-L1 antibodyAnti-Neuron Cytoplasmic Protein 9.5 antibodyAnti-Pgp 9.5 antibodyAnti-Pgp9.5 antibodyAnti-Ubiquitin Thioesterase L1 antibodyAnti-UCHL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance