Anti-Perforin antibody [ZM159] (STJ180367)


Current Stock:
Host: Mouse
Applications: IHC-p
Reactivity: Human
Short Description: Mouse monoclonal anti-Perforin antibody is suitable for use in Immunohistochemistry.
Clonality: Monoclonal
Clone ID: ZM159
Conjugation: Unconjugated
Formulation: Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Isotype: IgG Kappa
Dilution Range: 1:100‐200
Specificity: Positive control tissue: Spleen.
Immunogen: Recombinant human Perforin protein fragment (around aa 413‐552)
Immunogen Region: 413-552 aa
Background Perforin is a pore‐forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non‐ specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules and is known to be a key effector molecule for T‐cell‐ and natural killer‐cell‐ mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2) , a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T‐cells, natural killer cells and some CD4+ T‐ cells.

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12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance