||WB, IHC, ELISA
||Rabbit polyclonal anti-Perforin 1 antibody is suitable for use in Western Blot, Immunohistochemistry and ELISA.
||FOR RESEARCH USE ONLY (RUO).
||Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
||Store at-20°C, and avoid repeat freeze-thaw cycles.
||WB 1:500-2000IHC 1:50-200ELISA 1:10000-20000
||Perforin 1 polyclonal antibody detects endogenous levels of Perforin 1
||Synthesized peptide derived from Perforin 1
| Function || Pore-forming protein that plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. |
| Protein Name || Perforin-1P1CytolysinLymphocyte Pore-Forming ProteinPfp |
| Cellular Localisation || Cytoplasmic Granule LumenSecretedCell MembraneMulti-Pass Membrane ProteinEndosome LumenStored In Cytoplasmic Granules Of Cytolytic T-Lymphocytes And Secreted Into The Cleft Between T-Lymphocyte And Target CellInserts Into The Cell Membrane Of Target Cells And Forms PoresMembrane Insertion And Pore Formation Requires A Major Conformation ChangeMay Be Taken Up Via Endocytosis Involving Clathrin-Coated Vesicles And Accumulate In A First Time In Large Early Endosomes |
| Alternative Antibody Names || Anti-Perforin-1 antibodyAnti-P1 antibodyAnti-Cytolysin antibodyAnti-Lymphocyte Pore-Forming Protein antibodyAnti-Pfp antibodyAnti-PRF1 antibodyAnti-PFP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance