| Tissue Specificity | Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine. |
| Database Links | Reactome: R-HSA-111448 |
| Cellular Localisation | CytoplasmNucleusPml BodyEndoplasmic ReticulumMitochondrion MatrixCytoskeletonMicrotubule Organizing CenterCentrosomeInteraction With Banp Promotes Nuclear LocalizationRecruited Into Pml Bodies Together With Chek2Translocates To Mitochondria Upon Oxidative StressTranslocates To Mitochondria In Response To Mitomycin C TreatmentIsoform 1: NucleusPredominantly Nuclear But Localizes To The Cytoplasm When Expressed With Isoform 4Isoform 2: NucleusLocalized Mainly In The Nucleus With Minor Staining In The CytoplasmIsoform 3: NucleusLocalized In The Nucleus In Most Cells But Found In The Cytoplasm In Some CellsIsoform 4: NucleusPredominantly Nuclear But Translocates To The Cytoplasm Following Cell StressIsoform 7: NucleusIsoform 8: NucleusLocalized In Both Nucleus And Cytoplasm In Most CellsIn Some CellsForms Foci In The Nucleus That Are Different From NucleoliIsoform 9: Cytoplasm |
| Protein Name | Cellular Tumor Antigen P53Antigen Ny-Co-13Phosphoprotein P53Tumor Suppressor P53 |
| Alternative Names | Anti-Cellular Tumor Antigen P53 antibodyAnti-Antigen Ny-Co-13 antibodyAnti-Phosphoprotein P53 antibodyAnti-Tumor Suppressor P53 antibodyAnti-TP53 antibodyAnti-P53 antibody |
Information sourced from Uniprot.org
