Anti-p23 antibody [R03-2A6] (STJA0035307)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human p23/PTGES3
General Information
| Short Description | Rabbit monoclonal anti-p23 for use in WB, ICC, IF and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-2A6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PTGES3 |
| Gene ID | 10728 |
| Uniprot ID | TEBP_HUMAN |
| Immunogen | A synthetic peptide of human p23/PTGES3 |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation. |
| Function | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. |
| Protein Name | Prostaglandin E Synthase 3Cytosolic Prostaglandin E2 SynthaseCpgesHsp90 Co-ChaperoneProgesterone Receptor Complex P23Telomerase-Binding Protein P23 |
| Database Links | Reactome: R-HSA-2162123Reactome: R-HSA-3371497Reactome: R-HSA-3371511Reactome: R-HSA-3371568Reactome: R-HSA-8937144Reactome: R-HSA-8939211Reactome: R-HSA-9018519Reactome: R-HSA-9679191 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Prostaglandin E Synthase 3 antibodyAnti-Cytosolic Prostaglandin E2 Synthase antibodyAnti-Cpges antibodyAnti-Hsp90 Co-Chaperone antibodyAnti-Progesterone Receptor Complex P23 antibodyAnti-Telomerase-Binding Protein P23 antibodyAnti-PTGES3 antibodyAnti-P23 antibodyAnti-TEBP antibody |
Information sourced from Uniprot.org