| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-OPTC (20-115) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OPTC |
| Gene ID: |
26254 |
| Uniprot ID: |
OPT_HUMAN |
| Immunogen Region: |
20-115 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-115 of human OPTC (NP_055174.1). |
| Immunogen Sequence: |
ASLPRKERKRREEQMPREGD SFEVLPLRNDVLNPDNYGEV IDLSNYEELTDYGDQLPEVK VTSLAPATSISPAKSTTAPG TPSSNPTMTRPTTAGL |
| Tissue Specificity | Expressed in cartilage and synovial membranes (at protein level). Expressed in the retina, iris, ligament, skin and fetal liver (at protein level). Expressed in the retinal pigment epithelium (at protein level). Expressed in synovial fibroblasts and subchondral bone osteoblasts. |
| Post Translational Modifications | O-glycosylated. Proteolytically cleaved by MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, ADAMTS4, and ADAMTS5. Proteolytically cleaved by MMP13. The degradation of OPTC by proteases may contribute to osteoarthritis pathophysiology. Sulfated on tyrosine residues. |
| Function | Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization. Binds collagen fibrils. May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily. |
| Protein Name | OpticinOculoglycan |
| Database Links | Reactome: R-HSA-1474228 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Opticin antibodyAnti-Oculoglycan antibodyAnti-OPTC antibodyAnti-OPT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
