| Host: | Rabbit |
| Applications: | ELISA, WB |
| Reactivity: | Human, Mouse, Rat |
| Note: | FOR RESEARCH USE ONLY (RUO). |
| Short Description: | Rabbit polyclonal antibody anti-NRG3 is suitable for use in ELISA and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Biotin |
| Formulation: | Lyophilized from sterile filtered 0.01M PBS solution contaning 1% BSA and 15mM NaNO3 at a concentration of 2mg/ml. Upon receipt A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffe |
| Purification: | Serum IgG fraction was purified by Protein A affinity chromatography. |
| Dilution Range: | ELISA: Use at a concentration range of 1-2ug/ml. Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml. |
| Storage Instruction: | The lyophilized antibody is stable for at least 1 year from date of receipt at-20°C. Upon reconstitution, this antibody can be stored in working aliquots at 2°C-8°C for one month, or at-20°C for six months without detectable loss of activity. Avoid r |
| Gene Symbol: | NRG3 |
| Gene ID: | 10718 |
| Uniprot ID: | NRG3_HUMAN |
| Post Translational Modifications | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. Isoform 3 is glycosylated. |
| Function | Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. |
| Protein Name | Pro-Neuregulin-3 - Membrane-Bound IsoformPro-Nrg3 Cleaved Into - Neuregulin-3Nrg-3 |
| Database Links | Reactome: R-HSA-1227986Reactome: R-HSA-1236394Reactome: R-HSA-1250196Reactome: R-HSA-1250342Reactome: R-HSA-1250347Reactome: R-HSA-1251985Reactome: R-HSA-1257604Reactome: R-HSA-1963640Reactome: R-HSA-1963642Reactome: R-HSA-2219530Reactome: R-HSA-5673001Reactome: R-HSA-6785631Reactome: R-HSA-6811558Reactome: R-HSA-8847993Reactome: R-HSA-8863795Reactome: R-HSA-9664565Reactome: R-HSA-9665686 |
| Cellular Localisation | Pro-Neuregulin-3Membrane-Bound Isoform: Cell MembraneSingle-Pass Type I Membrane ProteinDoes Not Seem To Be ActiveNeuregulin-3: SecretedIsoform 3: Cell MembraneIsoform 3 Is Also Proteolytically Released As A Soluble Form |
| Alternative Antibody Names | Anti-Pro-Neuregulin-3 - Membrane-Bound Isoform antibodyAnti-Pro-Nrg3 Cleaved Into - Neuregulin-3 antibodyAnti-Nrg-3 antibodyAnti-NRG3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
