Anti-NRG3 antibody {Biotin} (STJA0003552)


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Host: Rabbit
Applications: ELISA, WB
Reactivity: Human, Mouse, Rat
Short Description: Rabbit polyclonal antibody anti-NRG3 is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Formulation: Lyophilized from sterile filtered 0.01M PBS solution contaning 1% BSA and 15mM NaNO3 at a concentration of 2mg/ml. Upon receipt A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffe
Purification: Serum IgG fraction was purified by Protein A affinity chromatography.
Dilution Range: ELISA: Use at a concentration range of 1-2ug/ml. Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 µg/ml.
Storage Instruction: The lyophilized antibody is stable for at least 1 year from date of receipt at-20°C. Upon reconstitution, this antibody can be stored in working aliquots at 2°C-8°C for one month, or at-20°C for six months without detectable loss of activity. Avoid r
Gene Symbol: NRG3
Gene ID: 10718
Uniprot ID: NRG3_HUMAN
Post Translational Modifications Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. Isoform 3 is glycosylated.
Function Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Protein Name Pro-Neuregulin-3 - Membrane-Bound Isoform
Pro-Nrg3 Cleaved Into - Neuregulin-3
Database Links Reactome: R-HSA-1227986
Reactome: R-HSA-1236394
Reactome: R-HSA-1250196
Reactome: R-HSA-1250342
Reactome: R-HSA-1250347
Reactome: R-HSA-1251985
Reactome: R-HSA-1257604
Reactome: R-HSA-1963640
Reactome: R-HSA-1963642
Reactome: R-HSA-2219530
Reactome: R-HSA-5673001
Reactome: R-HSA-6785631
Reactome: R-HSA-6811558
Reactome: R-HSA-8847993
Reactome: R-HSA-8863795
Reactome: R-HSA-9664565
Reactome: R-HSA-9665686
Cellular Localisation Pro-Neuregulin-3
Membrane-Bound Isoform: Cell Membrane
Single-Pass Type I Membrane Protein
Does Not Seem To Be Active
Neuregulin-3: Secreted
Isoform 3: Cell Membrane
Isoform 3 Is Also Proteolytically Released As A Soluble Form
Alternative Antibody Names Anti-Pro-Neuregulin-3 - Membrane-Bound Isoform antibody
Anti-Pro-Nrg3 Cleaved Into - Neuregulin-3 antibody
Anti-Nrg-3 antibody
Anti-NRG3 antibody

Information sourced from

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance