• Immunohistochemical stain on human esophagus.

Anti-MSH2 antibody (STJ160052)

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STJ160052
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Host: Mouse
Applications: IHC-p
Reactivity: Human
Short Description: Mouse monoclonal primary antibody against MSH2.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Monoclonal
Clone ID: IHC410
Conjugation: Unconjugated
Formulation: Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Storage Instruction: Store at 2-8°C. Do not freeze.
Dilution Range: 1:100-1:200
Uniprot ID: MSH2_HUMAN
Gene ID: 4436
Gene Symbol: MSH2
Immunogen: Human MSH2 protein.
Accession Number: P43246
Background MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development on sporadic colorectal carcinoma. Expression levels on MSH2 are abnormally low in a high percentage on patients with microsatellite instability, as well as endometrial and ovarian cancers. Use on Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection on the protein in a number on normal and neoplastic tissues, and for identifying a loss on MSH2 in tumors that are microsatellite-unstable.
Tissue Specificity Ubiquitously expressed.
Post Translational Modifications Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway.
Database Links Reactome: R-HSA-5358565
Cellular Localisation Nucleus
Chromosome
Protein Name Dna Mismatch Repair Protein Msh2
Hmsh2
Muts Protein Homolog 2
Alternative Names Anti-Dna Mismatch Repair Protein Msh2 antibody
Anti-Hmsh2 antibody
Anti-Muts Protein Homolog 2 antibody
Anti-MSH2 antibody

Information sourced from uniprot.org

6 months standard