| Background | MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development on sporadic colorectal carcinoma. Expression levels on MSH2 are abnormally low in a high percentage on patients with microsatellite instability, as well as endometrial and ovarian cancers. Use on Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection on the protein in a number on normal and neoplastic tissues, and for identifying a loss on MSH2 in tumors that are microsatellite-unstable. |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway. |
| Database Links | Reactome: R-HSA-5358565 |
| Cellular Localisation | NucleusChromosome |
| Protein Name | Dna Mismatch Repair Protein Msh2Hmsh2Muts Protein Homolog 2 |
| Alternative Names | Anti-Dna Mismatch Repair Protein Msh2 antibodyAnti-Hmsh2 antibodyAnti-Muts Protein Homolog 2 antibodyAnti-MSH2 antibody |
Information sourced from uniprot.org
