| Post Translational Modifications | All isoforms are N-glycosylated. Isoform E is O-glycosylated. Phosphorylated. |
| Function | Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner. Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B. |
| Protein Name | Megakaryocyte And Platelet Inhibitory Receptor G6bProtein G6b |
| Database Links | Reactome: R-HSA-114604 |
| Cellular Localisation | Isoform E: Endoplasmic ReticulumGolgi ApparatusIsoform D: Endoplasmic ReticulumIsoform B: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform A: Cell Membrane |
| Alternative Antibody Names | Anti-Megakaryocyte And Platelet Inhibitory Receptor G6b antibodyAnti-Protein G6b antibodyAnti-MPIG6B antibodyAnti-C6orf25 antibodyAnti-G6B antibodyAnti-G6B-B antibody |
Information sourced from Uniprot.org
