Anti-Methyl-2 NA-O-methyladenosine/Am-antibody (STJ11100889)


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Host: Rabbit
Applications: DB
Reactivity: Human, Mouse, Rat
Short Description: Rabbit polyclonal antibody anti-2 NA-O-methyladenosine/Am is suitable for use in Dot Blot.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: DB 1:500-1:2000
Storage Instruction: Store at-20°C. Avoid freeze/thaw cycles.
Immunogen: Chemical compounds corresponding to 2 NA-O-methyladenosine/Am.
Background Discovered in the 1970s, m6A is the most prevalent internal modification in polyadenylated mRNAs and long non-coding RNAs (lncRNAs) in higher eukaryotes. m6A is widely conserved among eukaryotic species that range from yeast, plants, flies to mammals, as well as among viral RNAs with a nuclear phase. The m6A-based modification is associated with a well-defined RNA motif, RRACH (R: A/G, H: A/C/U). As a representative of the epitranscriptome, m6A mRNA modifications participate in many vital activities in the cell, including stem cell self-renewal and differentiation, mRNA transcription, alternative splicing, nuclear export, translation, degradation, and microRNA processing. These processes determine the expression or inactivation of specific genes, which is vital for growth and development. (PMID: 30416848; PMID: 24662220; PMID: 30429466)

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