Anti-LYVE1 antibody [R03-3C1] (STJA0034537)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of mouse LYVE1
General Information
| Short Description | Rabbit monoclonal anti-LYVE1 for use in WB, IHC-P and IP in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-3C1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | Lyve1 |
| Gene ID | 114332 |
| Uniprot ID | LYVE1_MOUSE |
| Immunogen | Recombinant protein of mouse LYVE1 |
Additional Info
| Post Translational Modifications | O-glycosylated. |
| Function | Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium. |
| Protein Name | Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1Lyve-1Cell Surface Retention Sequence-Binding Protein 1Crsbp-1Extracellular Link Domain-Containing Protein 1 |
| Database Links | Reactome: R-MMU-2160916 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinLocalized To The Plasma Membrane And In Vesicles Near Extranuclear Membranes Which May Represent Trans-Golgi Network (Tgn) And Endosomes/Prelysosomeal CompartmentsUndergoes Ligand-Dependent Internalization And Recycling At The Cell Surface |
| Alternative Antibody Names | Anti-Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 antibodyAnti-Lyve-1 antibodyAnti-Cell Surface Retention Sequence-Binding Protein 1 antibodyAnti-Crsbp-1 antibodyAnti-Extracellular Link Domain-Containing Protein 1 antibodyAnti-Lyve1 antibodyAnti-Crsbp1 antibodyAnti-Xlkd1 antibody |
Information sourced from Uniprot.org