Anti-IRAK3 antibody (450-500) (STJ501491)

SKU:
STJ501491-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-IRAK3 (450-500) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: IRAK3
Gene ID: 11213
Uniprot ID: IRAK3_HUMAN
Immunogen Region: 450-500
Immunogen: Synthetic peptide taken within amino acid region 450-500 on mouse Interleukin-1 receptor-associated kinase 3 protein.
Tissue Specificity Expressed in eosinophils, dendritic cells and/or monocytes (at protein level). Expressed predominantly in peripheral blood lymphocytes.
Function Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells.
Protein Name Interleukin-1 Receptor-Associated Kinase 3
Irak-3
Il-1 Receptor-Associated Kinase M
Irak-M
Inactive Il-1 Receptor-Associated Kinase 3
Database Links Reactome: R-HSA-166058
Reactome: R-HSA-9020702
Cellular Localisation Cytoplasm
Nucleus
In Dendritic Cells
Translocates Into The Nucleus Upon Il33 Stimulation
Alternative Antibody Names Anti-Interleukin-1 Receptor-Associated Kinase 3 antibody
Anti-Irak-3 antibody
Anti-Il-1 Receptor-Associated Kinase M antibody
Anti-Irak-M antibody
Anti-Inactive Il-1 Receptor-Associated Kinase 3 antibody
Anti-IRAK3 antibody

Information sourced from Uniprot.org

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