• Immunohistochemistry of paraffin-embedded rat brain using IL33 antibody (STJ114478) (40x lens).
  • Immunohistochemistry of paraffin-embedded human esophagus using IL33 antibody (STJ114478) (40x lens).
  • Immunohistochemistry of paraffin-embedded human stomach using IL33 antibody (STJ114478) (40x lens).

Anti-IL33 antibody (STJ114478)

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Host: Rabbit
Applications: IHC
Reactivity: Human, Rat
Short Description: Rabbit polyclonal primary antibody against IL33.
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification: Affinity purification
Storage Instruction: Store at-20°C. Avoid freeze/thaw cycles.
Isotype: IgG
Dilution Range: IHC: 1:50-1:200
Uniprot ID: IL33_HUMAN
Gene ID: 90865
Gene Symbol: IL33
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human IL33 (NP_254274.1).
Background The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene.
Tissue Specificity Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.
Post Translational Modifications The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full length protein. May also be proteolytically processed by calpains. Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation. In vitro proteolytic cleavage by CASP1 was reported but could not be confirmed in vivo suggesting that IL33 is probably not a direct substrate for that caspase.
Function Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation.
Database Links Reactome: R-HSA-1257604
Cellular Localisation Nucleus
Cytoplasmic Vesicle
Secretory Vesicle
Associates With Heterochromatin And Mitotic Chromosomes
Protein Name Interleukin-33
Interleukin-1 Family Member 11
Nuclear Factor From High Endothelial Venules
Nf-Hev Cleaved Into - Interleukin-33
95-270 - Interleukin-33
99-270 - Interleukin-33
Alternative Names Anti-Interleukin-33 antibody
Anti-Il-33 antibody
Anti-Interleukin-1 Family Member 11 antibody
Anti-Il-1f11 antibody
Anti-Nuclear Factor From High Endothelial Venules antibody
Anti-Nf-Hev Cleaved Into - Interleukin-33 antibody
Anti-95-270 - Interleukin-33 antibody
Anti-99-270 - Interleukin-33 antibody
Anti-109-270 antibody
Anti-IL33 antibody
Anti-C9orf26 antibody
Anti-IL1F11 antibody
Anti-NFHEV antibody

Information sourced from uniprot.org

6 months standard