| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Hivep3 (617-714) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Hivep3 |
| Gene ID: |
16656 |
| Uniprot ID: |
ZEP3_MOUSE |
| Immunogen Region: |
617-714 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 617-714 of mouse Hivep3 (NP_034787.2). |
| Immunogen Sequence: |
KESDLTKKTKKGFKTKGANY ECTICGARYKKRDNYEAHKK YYCSELQITKAHSVGAHEVE KTQAEPEPWSQMMHYKLGAT LELTPLRKRRKEKSLGDE |
| Tissue Specificity | Expressed in macrophages, lymphocytes, brain, thymus, spleen and bone marrow. Expressed in osteoblasts, whole bone and, to a lesser extent, in osteoclasts. |
| Post Translational Modifications | Phosphorylated on threonine and serine residues. Phosphorylation by cyclin-dependent kinase CDK1 decreases HIVEP3 DNA binding affinity, and by epidermal growth factor receptor kinase increases its DNA binding affinity. |
| Function | Plays a role of transcription factor.binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments.Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation.Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus.through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. |
| Protein Name | Transcription Factor Hivep3Human Immunodeficiency Virus Type I Enhancer-Binding Protein 3 HomologKb-Binding And Recognition ComponentKappa-B And V(Dj Recombination Signal Sequences-Binding ProteinKappa-Binding Protein 1Kbp-1Recombinant ComponentSchnurri-3Zinc Finger Protein Zas3 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Transcription Factor Hivep3 antibodyAnti-Human Immunodeficiency Virus Type I Enhancer-Binding Protein 3 Homolog antibodyAnti-Kb-Binding And Recognition Component antibodyAnti-Kappa-B And V(Dj Recombination Signal Sequences-Binding Protein antibodyAnti-Kappa-Binding Protein 1 antibodyAnti-Kbp-1 antibodyAnti-Recombinant Component antibodyAnti-Schnurri-3 antibodyAnti-Zinc Finger Protein Zas3 antibodyAnti-Hivep3 antibodyAnti-KBP1 antibodyAnti-Kiaa1555 antibodyAnti-Krc antibodyAnti-Rc antibodyAnti-shn3 antibodyAnti-Zas3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
