Anti-GNB5 antibody (151-200 aa) (STJ93461)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GNB5 at the amino acid range 151-200
General Information
| Short Description | Rabbit polyclonal anti-Guanine nucleotide-binding protein subunit beta-5 (151-200 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GNB5 |
| Gene ID | 10681 |
| Uniprot ID | GNB5_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GNB5 at the amino acid range 151-200 |
| Immunogen Region | 151-200 aa |
| Specificity | G Beta 5 Polyclonal Antibody detects endogenous levels of G Beta 5 protein. |
Additional Info
| Function | Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation. Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition. Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors. May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate. |
| Protein Name | Guanine Nucleotide-Binding Protein Subunit Beta-5Gbeta5Transducin Beta Chain 5 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-202040Reactome: R-HSA-2514859 O14775-1Reactome: R-HSA-381676Reactome: R-HSA-392170Reactome: R-HSA-392451Reactome: R-HSA-392851Reactome: R-HSA-400042Reactome: R-HSA-4086398Reactome: R-HSA-416476Reactome: R-HSA-416482Reactome: R-HSA-418217Reactome: R-HSA-418555Reactome: R-HSA-418592Reactome: R-HSA-418594Reactome: R-HSA-418597Reactome: R-HSA-420092Reactome: R-HSA-428930Reactome: R-HSA-432040Reactome: R-HSA-456926Reactome: R-HSA-500657Reactome: R-HSA-6814122Reactome: R-HSA-8964315Reactome: R-HSA-8964616Reactome: R-HSA-9009391Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-9856530Reactome: R-HSA-997272 |
| Cellular Localisation | Membrane |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein Subunit Beta-5 antibodyAnti-Gbeta5 antibodyAnti-Transducin Beta Chain 5 antibodyAnti-GNB5 antibody |
Information sourced from Uniprot.org