• Western blot analysis of GSDMC Antibody. The lane on the right is blocked with the GSDMC peptide.
  • Western blot analysis of the lysates from HepG2 cells using GSDMC antibody.
  • Western blot analysis of various cells using Gasdermin C Polyclonal Antibody diluted at 1:500

Anti-Gasdermin C antibody (STJ93220)

SKU:
STJ93220

Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human
Short Description: Rabbit polyclonal anti-Gasdermin C antibody is suitable for use in Western Blot and ELISA.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Concentration: 1 mg/ml
Isotype: IgG
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Specificity: Gasdermin C polyclonal antibody detects endogenous levels of Gasdermin C protein.
Uniprot ID: GSDMC_HUMAN
Gene ID: 56169
Gene Symbol: GSDMC
Immunogen: Synthesized peptide derived from human Gasdermin C
Immunogen Region: 80-160 aa, Internal
Post Translational Modifications Cleavage relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-C, N-terminal) that initiates pyroptosis.
Function Gasdermin-C: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death. Gasdermin-C, N-terminal: Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (Probable).
Protein Name Gasdermin-C
Melanoma-Derived Leucine Zipper-Containing Extranuclear Factor Cleaved Into - Gasdermin-C - N-Terminal
Gsdmc-Nt - Gasdermin-C - C-Terminal
Gsdmc-Ct
Cellular Localisation Gasdermin-C: Cytoplasm
Cytosol
Gasdermin-C
N-Terminal: Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Gasdermin-C antibody
Anti-Melanoma-Derived Leucine Zipper-Containing Extranuclear Factor Cleaved Into - Gasdermin-C - N-Terminal antibody
Anti-Gsdmc-Nt - Gasdermin-C - C-Terminal antibody
Anti-Gsdmc-Ct antibody
Anti-GSDMC antibody
Anti-MLZE antibody

Information sourced from Uniprot.org

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