| Host: |
Rabbit |
| Applications: |
WB, ELISA |
| Reactivity: |
Human |
| Short Description: |
Rabbit polyclonal anti-Gasdermin C antibody is suitable for use in Western Blot and ELISA. |
| Note: |
FOR RESEARCH USE ONLY (RUO). |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Formulation: |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen. |
| Storage Instruction: |
Store at-20°C, and avoid repeat freeze-thaw cycles. |
| Concentration: |
1 mg/ml |
| Isotype: |
IgG |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Specificity: |
Gasdermin C polyclonal antibody detects endogenous levels of Gasdermin C protein. |
| Uniprot ID: |
GSDMC_HUMAN |
| Gene ID: |
56169 |
| Gene Symbol: |
GSDMC |
| Immunogen: |
Synthesized peptide derived from human Gasdermin C |
| Immunogen Region: |
80-160 aa, Internal |
| Post Translational Modifications | Cleavage relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-C, N-terminal) that initiates pyroptosis. |
| Function | Gasdermin-C: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death. Gasdermin-C, N-terminal: Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (Probable). |
| Protein Name | Gasdermin-CMelanoma-Derived Leucine Zipper-Containing Extranuclear Factor Cleaved Into - Gasdermin-C - N-TerminalGsdmc-Nt - Gasdermin-C - C-TerminalGsdmc-Ct |
| Cellular Localisation | Gasdermin-C: CytoplasmCytosolGasdermin-CN-Terminal: Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Gasdermin-C antibodyAnti-Melanoma-Derived Leucine Zipper-Containing Extranuclear Factor Cleaved Into - Gasdermin-C - N-Terminal antibodyAnti-Gsdmc-Nt - Gasdermin-C - C-Terminal antibodyAnti-Gsdmc-Ct antibodyAnti-GSDMC antibodyAnti-MLZE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
