Anti-FPR2 antibody (2-50 aa) (STJ13101097)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 2-50 of human FPR2 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-FPR2 (2-50 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | FPR2 |
| Gene ID | 2358 |
| Uniprot ID | FPR2_HUMAN |
| Immunogen | A synthetic peptide from aa region 2-50 of human FPR2 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | 2-50 aa |
| Specificity | Specific for FPR2. |
Additional Info
| Function | Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation. Acts as a receptor for humanin. |
| Protein Name | N-Formyl Peptide Receptor 2Fmlp-Related Receptor IFmlp-R-IFormyl Peptide Receptor-Like 1Hm63Lipoxin A4 ReceptorLxa4 ReceptorRfp |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-418594Reactome: R-HSA-444473Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinAssociates With Amyloid-Beta Protein 42Product Of AppAt The Cell Surface And The Complex Is Then Rapidly InternalizedAlso Internalized In The Presence Of Humanin |
| Alternative Antibody Names | Anti-N-Formyl Peptide Receptor 2 antibodyAnti-Fmlp-Related Receptor I antibodyAnti-Fmlp-R-I antibodyAnti-Formyl Peptide Receptor-Like 1 antibodyAnti-Hm63 antibodyAnti-Lipoxin A4 Receptor antibodyAnti-Lxa4 Receptor antibodyAnti-Rfp antibodyAnti-FPR2 antibodyAnti-FPRH1 antibodyAnti-FPRL1 antibodyAnti-LXA4R antibody |
Information sourced from Uniprot.org