Anti-FEZ1 antibody (STJA0008708)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human FEZ1
General Information
| Short Description | Rabbit polyclonal anti-Fasciculation and elongation protein zeta-1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FEZ1 |
| Gene ID | 9638 |
| Uniprot ID | FEZ1_HUMAN |
| Immunogen | Synthesized peptide derived from human FEZ1 |
| Specificity | This antibody detects endogenous levels of FEZ1 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Phosphorylated by protein kinase C zeta.which enhances interaction with UBE4B and polyubiquitination. Polyubiquitinated in a UBE4B-dependent manner.which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26. |
| Function | May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. |
| Protein Name | Fasciculation And Elongation Protein Zeta-1Zygin IZygin-1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCell MembraneColocalizes With BothAlpha- And Gamma-TubulinTranslocated From The Plasma Membrane To The Cytoplasm By Activation Of The Pkc Zeta |
| Alternative Antibody Names | Anti-Fasciculation And Elongation Protein Zeta-1 antibodyAnti-Zygin I antibodyAnti-Zygin-1 antibodyAnti-FEZ1 antibody |
Information sourced from Uniprot.org