Anti-DNAJC10 antibody (614-793) (STJ114036)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DNAJC10 (614-793) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DNAJC10 |
| Gene ID | 54431 |
| Uniprot ID | DJC10_HUMAN |
| Immunogen Region | 614-793 |
| Immunogen Sequence | IDCQQYHSFCAQENVQRYPE IRFFPPKSNKAYHYHSYNGW NRDAYSLRIWGLGFLPQVST DLTPQTFSEKVLQGKNHWVI DFYAPWCGPCQNFAPEFELL ARMIKGKVKAGKVDCQAYAQ TCQKAGIRAYPTVKFYFYER AKRNFQEEQINTRDAKAIAA LISEKLETLRNQGKRNKDEL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 614-793 of human DNAJC10 (NP_061854.1). |
Additional Info
| Function | Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. |
| Protein Name | Dnaj Homolog Subfamily C Member 10Endoplasmic Reticulum Dna J Domain-Containing Protein 5Er-Resident Protein Erdj5Erdj5MacrothioredoxinMthr |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily C Member 10 antibodyAnti-Endoplasmic Reticulum Dna J Domain-Containing Protein 5 antibodyAnti-Er-Resident Protein Erdj5 antibodyAnti-Erdj5 antibodyAnti-Macrothioredoxin antibodyAnti-Mthr antibodyAnti-DNAJC10 antibodyAnti-ERDJ5 antibodyAnti-UNQ495 antibodyAnti-PRO1012 antibody |
Information sourced from Uniprot.org