![Anti-DKK1 nanobody [SAA1268] (STJN000062)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200675/412857/STJN000062-SDS-PAGE-1__36120.1749232403.jpg?c=1 "Anti-DKK1 nanobody [SAA1268] (STJN000062)")
![Anti-DKK1 nanobody [SAA1268] (STJN000062)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200675/412857/STJN000062-SDS-PAGE-1__36120.1749232403.jpg?c=1 "Anti-DKK1 nanobody [SAA1268] (STJN000062)")
Anti-DKK1 nanobody [SAA1268] (STJN000062)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Dickkopf-Related Protein 1 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1268 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | DKK1 |
| Gene ID | 22943 |
| Uniprot ID | DKK1_HUMAN |
Additional Info
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. |
| Protein Name | Dickkopf-Related Protein 1Dickkopf-1Dkk-1Hdkk-1Sk |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470Reactome: R-HSA-5339717 |
| Cellular Localisation | Secreted |
| Alternative Nanobody Names | Anti-Dickkopf-Related Protein 1 nanobodyAnti-Dickkopf-1 nanobodyAnti-Dkk-1 nanobodyAnti-Hdkk-1 nanobodyAnti-Sk nanobodyAnti-DKK1 nanobodyAnti-UNQ492 nanobodyAnti-PRO1008 nanobody |
Information sourced from Uniprot.org