| Background | This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. |
| Tissue Specificity | Liver. |
| Function | Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity. |
| Database Links | Reactome: R-HSA-211981 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Protein Name | Cytochrome P450 2a61 -4-Cineole 2-Exo-MonooxygenaseCypiia6Coumarin 7-HydroxylaseCytochrome P450 Iia3Cytochrome P450(I |
| Alternative Names | Anti-Cytochrome P450 2a6 antibodyAnti-1 -4-Cineole 2-Exo-Monooxygenase antibodyAnti-Cypiia6 antibodyAnti-Coumarin 7-Hydroxylase antibodyAnti-Cytochrome P450 Iia3 antibodyAnti-Cytochrome P450(I antibodyAnti-CYP2A6 antibodyAnti-CYP2A3 antibody |
Information sourced from uniprot.org
