Anti-CILP antibody (STJ192071)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Cartilage intermediate layer protein 1 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CILP |
| Gene ID | 8483 |
| Uniprot ID | CILP1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | CILP1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion. |
| Function | Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. |
| Protein Name | Cartilage Intermediate Layer Protein 1Cilp-1Cartilage Intermediate-Layer Protein Cleaved Into - Cartilage Intermediate Layer Protein 1 C1 - Cartilage Intermediate Layer Protein 1 C2 |
| Database Links | Reactome: R-HSA-2404192 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Cartilage Intermediate Layer Protein 1 antibodyAnti-Cilp-1 antibodyAnti-Cartilage Intermediate-Layer Protein Cleaved Into - Cartilage Intermediate Layer Protein 1 C1 - Cartilage Intermediate Layer Protein 1 C2 antibodyAnti-CILP antibodyAnti-UNQ602 antibodyAnti-PRO1188 antibody |
Information sourced from Uniprot.org