| Host: |
Rat |
| Applications: |
FC |
| Reactivity: |
Mouse |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rat monoclonal antibody anti-Integrin alpha-V is suitable for use in Flow Cytometry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
RMV-7 |
| Conjugation: |
PE |
| Isotype: |
IgG1k |
| Formulation: |
PBS with 0.05% Proclin300, 1% BSA |
| Concentration: |
0.2 mg/mL |
| Storage Instruction: |
Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
| Function | The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation. ITGAV:ITGB3 acts as a receptor for CD40LG. ITGAV:ITGB3 binds to the Lilrb4a/Gp49b receptor and enhances the Lilrb4a-mediated inhibition of mast cell activation. ITGAV:ITGB3 also suppresses marginal zone B cell antibody production through its interaction with Lilrb4a. |
| Protein Name | Integrin Alpha-VVitronectin Receptor Subunit AlphaCd Antigen Cd51 Cleaved Into - Integrin Alpha-V Heavy Chain - Integrin Alpha-V Light Chain |
| Database Links | Reactome: R-MMU-1236973Reactome: -MMU-1566948Reactome: -MMU-210990Reactome: -MMU-2129379Reactome: -MMU-216083Reactome: -MMU-2173789Reactome: -MMU-3000170Reactome: -MMU-3000178Reactome: -MMU-4420097Reactome: -MMU-445144Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionFocal Adhesion |
| Alternative Antibody Names | Anti-Integrin Alpha-V antibodyAnti-Vitronectin Receptor Subunit Alpha antibodyAnti-Cd Antigen Cd51 Cleaved Into - Integrin Alpha-V Heavy Chain - Integrin Alpha-V Light Chain antibodyAnti-Itgav antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
