| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CMRF35-like molecule 1 (41-90 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CD300LF |
| Gene ID: |
146722 |
| Uniprot ID: |
CLM1_HUMAN |
| Immunogen Region: |
41-90 aa |
| Specificity: |
CD300f Polyclonal Antibody detects endogenous levels of CD300f protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human CD300LF at the amino acid range 41-90 |
| Post Translational Modifications | Phosphorylated on tyrosine. |
| Function | Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition.recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement. |
| Protein Name | Cmrf35-Like Molecule 1Clm-1Cd300 Antigen-Like Family Member FImmune Receptor Expressed On Myeloid Cells 1Irem-1Immunoglobulin Superfamily Member 13Igsf13Nk Inhibitory ReceptorCd Antigen Cd300f |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cmrf35-Like Molecule 1 antibodyAnti-Clm-1 antibodyAnti-Cd300 Antigen-Like Family Member F antibodyAnti-Immune Receptor Expressed On Myeloid Cells 1 antibodyAnti-Irem-1 antibodyAnti-Immunoglobulin Superfamily Member 13 antibodyAnti-Igsf13 antibodyAnti-Nk Inhibitory Receptor antibodyAnti-Cd Antigen Cd300f antibodyAnti-CD300LF antibodyAnti-CD300F antibodyAnti-CLM1 antibodyAnti-IGSF13 antibodyAnti-IREM1 antibodyAnti-NKIR antibodyAnti-UNQ3105 antibodyAnti-PRO10111 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
