• Immunohistochemical stain on human lung.

Anti-CD274 antibody [IHC411] (STJ160016)


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Host: Rabbit
Applications: IHC-p
Reactivity: Human
Short Description: Rabbit monoclonal anti-CD274 antibody is suitable for use in Immunohistochemistry.
Clonality: Monoclonal
Clone ID: IHC411
Conjugation: Unconjugated
Formulation: Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Storage Instruction: Store at 2-8°C. Do not freeze.
Dilution Range: 1:100-1:200
Uniprot ID: PD1L1_HUMAN
Gene ID: 29126
Gene Symbol: CD274
Immunogen: Human PD-L1 protein.
Accession Number: Q9NZQ7
Tissue Specificity Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
Post Translational Modifications Ubiquitinated.STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.
Function Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.
Protein Name Programmed Cell Death 1 Ligand 1
Pdcd1 Ligand 1
Programmed Death Ligand 1
B7 Homolog 1
Cd Antigen Cd274
Database Links Reactome: R-HSA-389948
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Early Endosome Membrane
Recycling Endosome Membrane
Associates With Cmtm6 At Recycling Endosomes
Where It Is Protected From Being Targeted For Lysosomal Degradation
Isoform 1: Cell Membrane
Isoform 2: Endomembrane System
Alternative Antibody Names Anti-Programmed Cell Death 1 Ligand 1 antibody
Anti-Pd-L1 antibody
Anti-Pdcd1 Ligand 1 antibody
Anti-Programmed Death Ligand 1 antibody
Anti-Hpd-L1 antibody
Anti-B7 Homolog 1 antibody
Anti-B7-H1 antibody
Anti-Cd Antigen Cd274 antibody
Anti-CD274 antibody
Anti-B7H1 antibody
Anti-PDCD1L1 antibody
Anti-PDCD1LG1 antibody
Anti-PDL1 antibody

Information sourced from Uniprot.org

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