||Rabbit monoclonal anti-CD274 antibody is suitable for use in Immunohistochemistry.
||FOR RESEARCH USE ONLY (RUO).
||Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
||Store at 2-8°C. Do not freeze.
||Human PD-L1 protein.
| Tissue Specificity || Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. |
| Post Translational Modifications || Ubiquitinated.STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation. |
| Function || Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy. |
| Protein Name || Programmed Cell Death 1 Ligand 1Pd-L1Pdcd1 Ligand 1Programmed Death Ligand 1Hpd-L1B7 Homolog 1B7-H1Cd Antigen Cd274 |
| Database Links || Reactome: R-HSA-389948 |
| Cellular Localisation || Cell MembraneSingle-Pass Type I Membrane ProteinEarly Endosome MembraneRecycling Endosome MembraneAssociates With Cmtm6 At Recycling EndosomesWhere It Is Protected From Being Targeted For Lysosomal DegradationIsoform 1: Cell MembraneIsoform 2: Endomembrane System |
| Alternative Antibody Names || Anti-Programmed Cell Death 1 Ligand 1 antibodyAnti-Pd-L1 antibodyAnti-Pdcd1 Ligand 1 antibodyAnti-Programmed Death Ligand 1 antibodyAnti-Hpd-L1 antibodyAnti-B7 Homolog 1 antibodyAnti-B7-H1 antibodyAnti-Cd Antigen Cd274 antibodyAnti-CD274 antibodyAnti-B7H1 antibodyAnti-PDCD1L1 antibodyAnti-PDCD1LG1 antibodyAnti-PDL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance