Anti-CD16 antibody [EP364] (STJ180346)


Current Stock:
Host: Rabbit
Applications: IHC-p
Reactivity: Human
Short Description: Rabbit monoclonal anti-CD16 antibody is suitable for use in Immunohistochemistry.
Clonality: Monoclonal
Clone ID: EP364
Conjugation: Unconjugated
Formulation: Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Isotype: IgG
Dilution Range: 1:50‐100
Specificity: Positive control tissue: Bone Marrow.
Immunogen: Recombinant human CD16 protein
Background CD16 is a biomarker associated with monocytes and natural killer (NK) cells of the lymphoid lineage. Anti‐CD16 immunohistochemistry is useful in differentially diagnosing hepatosplenic gamma delta T‐cell lymphoma and gamma delta T‐cell large granular lymphocyte leukemia from other peripheral T‐cell lymphomas, such as mucosal and cutaneous gamma delta T‐cell lymphoma. A significant decrease can be seen in the number of granulocytes expressing CD16 in chronic myelomonocytic leukemia compared to chronic myelogenous leukemia and control bone marrow biopsy, probably related to dysgranulopoiesis. Bone marrow biopsy immunohistochemistry can be helpful in CMML by identifying both the monocyte expansion and the dysgranulopoiesis with anti‐CD1

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12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance