| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-CCNA1 (350-450) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCNA1 |
| Gene ID: | 8900 |
| Uniprot ID: | CCNA1_HUMAN |
| Immunogen Region: | 350-450 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human CCNA1 (NP_001104515.1). |
| Immunogen Sequence: | YLRRQGVCVRTENLAKYVAE LSLLEADPFLKYLPSLIAAA AFCLANYTVNKHFWPETLAA FTGYSLSEIVPCLSELHKAY LDIPHRPQQAIREKYKASKY L |
| Tissue Specificity | Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines. |
| Post Translational Modifications | Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. |
| Function | May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. |
| Protein Name | Cyclin-A1 |
| Database Links | Reactome: R-HSA-1538133Reactome: R-HSA-170145Reactome: R-HSA-171319Reactome: R-HSA-174184Reactome: R-HSA-176408Reactome: R-HSA-187577Reactome: R-HSA-2559582Reactome: R-HSA-2559586Reactome: R-HSA-5689880Reactome: R-HSA-5693607Reactome: R-HSA-6804116Reactome: R-HSA-6804756Reactome: R-HSA-6804757Reactome: R-HSA-68911Reactome: R-HSA-68949Reactome: R-HSA-69017Reactome: R-HSA-69205Reactome: R-HSA-69273Reactome: R-HSA-69563Reactome: R-HSA-69656 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclin-A1 antibodyAnti-CCNA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
