Anti-CBX2 antibody [R01-1R7] (STJA0037144)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human CBX2
General Information
| Short Description | Rabbit monoclonal anti-CBX2 for use in WB and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-1R7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CBX2 |
| Gene ID | 84733 |
| Uniprot ID | CBX2_HUMAN |
| Immunogen | A synthesized peptide derived from human CBX2 |
Additional Info
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). Plays a role in the lineage differentiation of the germ layers in embryonic development. Involved in sexual development, acting as activator of NR5A1 expression. |
| Protein Name | Chromobox Protein Homolog 2 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-3108214Reactome: R-HSA-3899300Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4655427Reactome: R-HSA-8939243Reactome: R-HSA-8943724 |
| Cellular Localisation | NucleusChromosomeLocalized In Distinct Foci On Chromatin And In ChromocentersLocalizes To The Inactive X ChromosomeSeems To Be Recruited To H3k27me3H3k9ac And H3k3me2 Sites On Chromatin |
| Alternative Antibody Names | Anti-Chromobox Protein Homolog 2 antibodyAnti-CBX2 antibody |
Information sourced from Uniprot.org