Anti-Capsaicin Receptor antibody (STJ16101295)

SKU:
STJ16101295

Current Stock:
Host: Rabbit
Applications: IHC-F
Reactivity: Rat
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody anti-Capsaicin Receptor is suitable for use in Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: Lyophilized; reconstitute in 100 µl dist. water
Dilution Range: IHC-F (1:1
500-1:2
500)
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: TRPV1
Gene ID: 7442
Uniprot ID: TRPV1_HUMAN
Tissue Specificity Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).
Post Translational Modifications Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phosphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.
Function Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.
Protein Name Transient Receptor Potential Cation Channel Subfamily V Member 1
Trpv1
Capsaicin Receptor
Osm-9-Like Trp Channel 1
Otrpc1
Vanilloid Receptor 1
Database Links Reactome: R-HSA-3295583
Cellular Localisation Cell Junction
Synapse
Postsynaptic Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Dendritic Spine Membrane
Cell Membrane
Mostly
But Not Exclusively Expressed In Postsynaptic Dendritic Spines
Alternative Antibody Names Anti-Transient Receptor Potential Cation Channel Subfamily V Member 1 antibody
Anti-Trpv1 antibody
Anti-Capsaicin Receptor antibody
Anti-Osm-9-Like Trp Channel 1 antibody
Anti-Otrpc1 antibody
Anti-Vanilloid Receptor 1 antibody
Anti-TRPV1 antibody
Anti-VR1 antibody

Information sourced from Uniprot.org

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