• Immunohistochemical analysis of paraffin-embedded Mouse Brain Tissue using CaMKII Beta/Gamma/Delta (Phospho Thr287) Mouse mAb diluted at 1:200.
  • Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using CaMKII Beta/Gamma/Delta (Phospho Thr287) (mAb diluted at 1:200.

Anti-CaMKI Beta/gamma/delta (Phospho Thr287) antibody [4H2] (STJ97535)

SKU:
STJ97535

Current Stock:
Host: Mouse
Applications: IHC-P
Reactivity: Human, Rat, Mouse
Short Description: Mouse monoclonal anti-CaMKI Beta/gamma/delta (Phospho Thr287) antibody is suitable for use in Immunohistochemistry.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Monoclonal
Clone ID: 4H2
Conjugation: Unconjugated
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using a specific immunogen.
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Concentration: 1 mg/ml
Isotype: IgG1
Dilution Range: IHC 1:100-200
Specificity: CaMKII beta/gamma/delta (Phospho Thr287) protein detects endogenous levels of CaMKII beta/gamma/delta (Phospho Thr287)
Uniprot ID: KCC2B_HUMAN
Gene ID: 816
Gene Symbol: CAMK2B
Immunogen: Synthetic Peptide
Post Translational Modifications Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
Function Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
Protein Name Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Beta
Cam Kinase Ii Subunit Beta
Camk-Ii Subunit Beta
Database Links Reactome: R-HSA-111932
Reactome: R-HSA-3371571
Reactome: R-HSA-399719
Reactome: R-HSA-438066
Reactome: R-HSA-442729
Reactome: R-HSA-442982
Reactome: R-HSA-5576892
Reactome: R-HSA-5578775
Reactome: R-HSA-5673000
Reactome: R-HSA-5673001
Reactome: R-HSA-6802946
Reactome: R-HSA-6802952
Reactome: R-HSA-6802955
Reactome: R-HSA-877300
Reactome: R-HSA-9022692
Reactome: R-HSA-936837
Reactome: R-HSA-9609736
Reactome: R-HSA-9617324
Reactome: R-HSA-9620244
Reactome: R-HSA-9649948
Reactome: R-HSA-9656223
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Sarcoplasmic Reticulum Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cell Junction
Synapse
In Slow-Twitch Muscle
Evenly Distributed Between Longitudinal Sr And Junctional Sr
Alternative Antibody Names Anti-Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Beta antibody
Anti-Cam Kinase Ii Subunit Beta antibody
Anti-Camk-Ii Subunit Beta antibody
Anti-CAMK2B antibody
Anti-CAM2 antibody
Anti-CAMK2 antibody
Anti-CAMKB antibody

Information sourced from Uniprot.org

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