• Formalin-fixed, paraffin-embedded human neuroendocrine tumor stained with anti-ATRX polyclonal antibody using peroxidase-conjugate and DAB chromogen . Note nuclear staining of neoplastic cells
  • Formalin-fixed, paraffin-embedded human neuroendocrine tumor stained with anti-ATRX polyclonal antibody using peroxidase-conjugate and DAB chromogen . Note nuclear staining of neoplastic cells
  • Formalin-fixed, paraffin-embedded human neuroendocrine tumor stained with anti-ATRX polyclonal antibody using peroxidase-conjugate and DAB chromogen . Note nuclear staining of neoplastic cells
  • Formalin-fixed, paraffin-embedded human neuroendocrine tumor stained with anti-ATRX polyclonal antibody using peroxidase-conjugate and DAB chromogen . Note nuclear staining of neoplastic cells
  • Formalin-fixed, paraffin-embedded human neuroendocrine tumor stained with anti-ATRX polyclonal antibody using peroxidase-conjugate and DAB chromogen . Note nuclear staining of neoplastic cells
  • Formalin-fixed, paraffin-embedded human neuroendocrine tumor stained with anti-ATRX polyclonal antibody using peroxidase-conjugate and DAB chromogen . Note nuclear staining of neoplastic cells

Anti-ATRX antibody [Poly] (STJ180012)

SKU:
STJ180012

Current Stock:
Host: Rabbit
Applications: IHC-p
Reactivity: Human
Short Description: Rabbit polyclonal anti-ATRX antibody is suitable for use in Immunohistochemistry.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Polyclonal
Clone ID: Poly
Conjugation: Unconjugated
Formulation: Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Isotype: IgG
Dilution Range: 1:25‐50
Specificity: Positive control tissue: High-grade glioma.
Uniprot ID: ATRX_HUMAN
Gene ID: 546
Gene Symbol: ATRX
Immunogen: Synthetic peptidefrom human ATRX protein
Tissue Specificity Ubiquitous.
Post Translational Modifications Phosphorylated at serine residues during mitose. Phosphorylation may promote the release from the nuclear matrix and progression to mitosis.
Function Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting.according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts. May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes.
Protein Name Transcriptional Regulator Atrx
Atp-Dependent Helicase Atrx
X-Linked Helicase Ii
X-Linked Nuclear Protein
Xnp
Znf-Hx
Database Links Reactome: R-HSA-9670095
Cellular Localisation Nucleus
Chromosome
Telomere
Pml Body
Associated With Pericentromeric Heterochromatin During Interphase And Mitosis
Probably By Interacting With Cbx5/Hp1 Alpha
Colocalizes With Histone H3
Daxx
Hira And Asf1a At Pml-Nuclear Bodies
Colocalizes With Cohesin (Smc1 And Smc3) And Mecp2 At The Maternal H19 Icr
Alternative Antibody Names Anti-Transcriptional Regulator Atrx antibody
Anti-Atp-Dependent Helicase Atrx antibody
Anti-X-Linked Helicase Ii antibody
Anti-X-Linked Nuclear Protein antibody
Anti-Xnp antibody
Anti-Znf-Hx antibody
Anti-ATRX antibody
Anti-RAD54L antibody
Anti-XH2 antibody

Information sourced from Uniprot.org

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