Anti-ATN1 antibody (900-1040 aa) (STJ11106578)

SKU:
STJ11106578

£112.50 - £524.50
Current Stock:
Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: ATN1
Gene ID: 1822
Uniprot ID: ATN1_HUMAN
Immunogen Region: 900-1040 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 900-1040 of human ATN1 (NP_001007027.1).
Immunogen Sequence: RNHPFYVPLGAVDPGLLGYN VPALYSSDPAAREREREARE RDLRDRLKPGFEVKPSELEP LHGVPGPGLDPFPRHGGLAL QPGPPGLHPFPFHPSLGPLE RERLALAAGPALRPDMSYAE RLAAERQHAERVAALGNDPL A
Tissue Specificity Widely expressed in various tissues including heart, lung, kidney, ovary, testis, prostate, placenta, skeletal Low levels in the liver, thymus and leukocytes. In the adult brain, broadly expressed in amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus, and thalamus. High levels in fetal tissues, especially brain.
Post Translational Modifications Phosphorylated in vitro by MAPK8/JNK1 on Ser-739. Mutant ATN1 sequences with expanded poly-Gln (polyQ) traits are more slowly phosphorylated. Proteolytically cleaved, probably in the nucleus, to produce two C-terminal fragments of 140 kDa (F1) and 125 kDa (F2) each containing poly-Gln (polyQ) tracts. F2 is produced by cleavage by caspases and is exported into the cytoplasm. In vitro, cleavage increases with an increase in the number of polyQ tracts. C-terminal proteolytic products appear to be the cause of cell toxicity. In vitro cleavage at Asp-109.
Function Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats.
Protein Name Atrophin-1
Dentatorubral-Pallidoluysian Atrophy Protein
Database Links Reactome: R-HSA-8943724
Cellular Localisation Nucleus
Cytoplasm
Perinuclear Region
Cell Junction
Shuttles Between Nucleus And Cytoplasm
Colocalizes With Fat1 In The Perinuclear Area
At Cell-Cell Junctions And Leading Edges Of Cells
Colocalizes With Mtg8 In Discrete Nuclear Dots
Proteolytic Fragment F1 Appears To Remain In Nucleus
Fragment F2 Is Exported Into The Cytoplasm
Fragment F2 From Mutant Sequences With Longer Poly-Gln (Polyq) Tracts Are Additionally Located To The Cytoplasmic Membrane And To Certain Organelles
Alternative Antibody Names Anti-Atrophin-1 antibody
Anti-Dentatorubral-Pallidoluysian Atrophy Protein antibody
Anti-ATN1 antibody
Anti-D12S755E antibody
Anti-DRPLA antibody

Information sourced from Uniprot.org

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