| Function | Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway. |
| Protein Name | Aspartate Aminotransferase - CytoplasmicCaspatCysteine Aminotransferase - CytoplasmicCysteine Transaminase - CytoplasmicCcatGlutamate Oxaloacetate Transaminase 1Transaminase A |
| Database Links | Reactome: R-HSA-1237112Reactome: R-HSA-8963693Reactome: R-HSA-9856872 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Aspartate Aminotransferase - Cytoplasmic antibodyAnti-Caspat antibodyAnti-Cysteine Aminotransferase - Cytoplasmic antibodyAnti-Cysteine Transaminase - Cytoplasmic antibodyAnti-Ccat antibodyAnti-Glutamate Oxaloacetate Transaminase 1 antibodyAnti-Transaminase A antibodyAnti-GOT1 antibody |
Information sourced from Uniprot.org
