| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AT-rich interactive domain-containing protein 1A (1270-1350 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-300IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARID1A |
| Gene ID: |
8289 |
| Uniprot ID: |
ARI1A_HUMAN |
| Immunogen Region: |
1270-1350 aa |
| Specificity: |
ARI1A Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 1270-1350 |
| Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
| Protein Name | At-Rich Interactive Domain-Containing Protein 1aArid Domain-Containing Protein 1aB120Brg1-Associated Factor 250Baf250Brg1-Associated Factor 250aBaf250aOsa Homolog 1Hosa1Swi-Like ProteinSwi/Snf Complex Protein P270Swi/Snf-Related - Matrix-Associated - Actin-Dependent Regulator Of Chromatin Subfamily F Member 1Held |
| Database Links | Reactome: R-HSA-3214858Reactome: R-HSA-8939243 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-At-Rich Interactive Domain-Containing Protein 1a antibodyAnti-Arid Domain-Containing Protein 1a antibodyAnti-B120 antibodyAnti-Brg1-Associated Factor 250 antibodyAnti-Baf250 antibodyAnti-Brg1-Associated Factor 250a antibodyAnti-Baf250a antibodyAnti-Osa Homolog 1 antibodyAnti-Hosa1 antibodyAnti-Swi-Like Protein antibodyAnti-Swi/Snf Complex Protein P270 antibodyAnti-Swi/Snf-Related - Matrix-Associated - Actin-Dependent Regulator Of Chromatin Subfamily F Member 1 antibodyAnti-Held antibodyAnti-ARID1A antibodyAnti-BAF250 antibodyAnti-BAF250A antibodyAnti-C1orf4 antibodyAnti-OSA1 antibodyAnti-SMARCF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
