• Immunohistochemistry analysis of AQR in paraffin-embedded mouse testis using AQR Rabbit polyclonal antibody (STJ117823) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of AQR in paraffin-embedded human lung cancer using AQR Rabbit polyclonal antibody (STJ117823) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of AQR in paraffin-embedded rat spleen using AQR Rabbit polyclonal antibody (STJ117823) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of various lysates using AQR Rabbit polyclonal antibody (STJ117823) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 40s.

Anti-AQR antibody (400-700) (STJ117823)

SKU:
STJ117823

£169.50 - £449.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-AQR (400-700) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AQR
Gene ID: 9716
Uniprot ID: AQR_HUMAN
Immunogen Region: 400-700
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human AQR (NP_055506.1).
Immunogen Sequence: KEFLLELLVSRHERRISQIQ QLNQMPLYPTEKIIWDENIV PTEYYSGEGCLALPKLNLQF LTLHDYLLRNFNLFRLESTY EIRQDIEDSVSRMKPWQSEY GGVVFGGWARMAQPIVAFTV VEVAKPNIGENWPTRVRADV TINLNVRDHIKDEWEGLRKH DVCFLITVRPTKPYGTKFDR RRPFIEQVGLVYVRGCEIQG MLDDKGRVIEDGPEPRPNLR GESRTFRVFLDPNQYQQDM
Function Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro).
Protein Name Rna Helicase Aquarius
Intron-Binding Protein Of 160 Kda
Ibp160
Database Links Reactome: R-HSA-6781823
Reactome: R-HSA-6781827
Reactome: R-HSA-6782135
Reactome: R-HSA-6782210
Reactome: R-HSA-72163
Cellular Localisation Nucleus
Nucleoplasm
Localizes To Speckle-Like Regions Of The Nucleoplasm
Alternative Antibody Names Anti-Rna Helicase Aquarius antibody
Anti-Intron-Binding Protein Of 160 Kda antibody
Anti-Ibp160 antibody
Anti-AQR antibody
Anti-KIAA0560 antibody

Information sourced from Uniprot.org

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