| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-APPBP2 (386-585) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
APPBP2 |
| Gene ID: |
10513 |
| Uniprot ID: |
APBP2_HUMAN |
| Immunogen Region: |
386-585 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 386-585 of human APPBP2 (NP_006371.2). |
| Immunogen Sequence: |
LEEIAIDCHNKETEQRLLQE AHDLHLSSLQLAKKAFGEFN VQTAKHYGNLGRLYQSMRKF KEAEEMHIKAIQIKEQLLGQ EDYEVALSVGHLASLYNYDM NQYENAEKLYLRSIAIGKKL FGEGYSGLEYDYRGLIKLYN SIGNYEKVFEYHNVLSNWNR LRDRQYSVTDALEDVSTSPQ STEEVVQSFLISQNVEGPSC |
| Post Translational Modifications | Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP. |
| Function | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron. May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface. |
| Protein Name | Amyloid Protein-Binding Protein 2Amyloid Beta Precursor Protein-Binding Protein 2App-Bp2Protein Interacting With App Tail 1 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMembranePeripheral Membrane ProteinAssociated With Membranes And Microtubules |
| Alternative Antibody Names | Anti-Amyloid Protein-Binding Protein 2 antibodyAnti-Amyloid Beta Precursor Protein-Binding Protein 2 antibodyAnti-App-Bp2 antibodyAnti-Protein Interacting With App Tail 1 antibodyAnti-APPBP2 antibodyAnti-KIAA0228 antibodyAnti-PAT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
