| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ANAPC2 (400-500) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:100-1:500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ANAPC2 |
| Gene ID: | 29882 |
| Uniprot ID: | ANC2_HUMAN |
| Immunogen Region: | 400-500 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human ANAPC2 (NP_037498.1). |
| Immunogen Sequence: | YISAIKALRVLDPSMVILEV ACEPIRRYLRTREDTVRQIV AGLTGDSDGTGDLAVELSKT DPASLETGQDSEDDSGEPED WVPDPVDADPGKSSSKRRSS D |
| Function | Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. |
| Protein Name | Anaphase-Promoting Complex Subunit 2Apc2Cyclosome Subunit 2 |
| Database Links | Reactome: R-HSA-141430Reactome: R-HSA-174048Reactome: R-HSA-174084Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-174184Reactome: R-HSA-176407Reactome: R-HSA-176408Reactome: R-HSA-176409Reactome: R-HSA-176412Reactome: R-HSA-179409Reactome: R-HSA-2467813Reactome: R-HSA-2559582Reactome: R-HSA-68867Reactome: R-HSA-69017Reactome: R-HSA-8853884Reactome: R-HSA-9687136Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-Anaphase-Promoting Complex Subunit 2 antibodyAnti-Apc2 antibodyAnti-Cyclosome Subunit 2 antibodyAnti-ANAPC2 antibodyAnti-APC2 antibodyAnti-KIAA1406 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
