• Western blot analysis of extracts of various cell lines, using ADCY3 antibody (STJ110180) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.

Anti-ADCY3 antibody (1-80) (STJ110180)


Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human, Mouse
Short Description: Rabbit polyclonal antibody anti-ADCY3 (1-80) is suitable for use in Western Blot.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS containing 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store in a freezer at-20°C and avoid freeze-thaw cycles.
Gene Symbol: ADCY3
Gene ID: 109
Immunogen Region: 1-80
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ADCY3 (NP_004027.2).
Tissue Specificity Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle. Detected in testis.
Post Translational Modifications Sumoylated. Sumoylation is required for targeting ot olfactory cilia. N-glycosylated. Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity.
Function Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
Protein Name Adenylate Cyclase Type 3
Atp Pyrophosphate-Lyase 3
Adenylate Cyclase Type Iii
Adenylate Cyclase - Olfactive Type
Adenylyl Cyclase 3
Database Links Reactome: R-HSA-163359
Reactome: R-HSA-163615
Reactome: R-HSA-164378
Reactome: R-HSA-170660
Reactome: R-HSA-170670
Reactome: R-HSA-418555
Reactome: R-HSA-418594
Reactome: R-HSA-418597
Reactome: R-HSA-432040
Reactome: R-HSA-5610787
Reactome: R-HSA-9660821
Reactome: R-HSA-9664323
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Golgi Apparatus
Also Detected In The Cytoplasm
Close To Lipid Droplets
Alternative Antibody Names Anti-Adenylate Cyclase Type 3 antibody
Anti-Atp Pyrophosphate-Lyase 3 antibody
Anti-Adenylate Cyclase Type Iii antibody
Anti-Ac-Iii antibody
Anti-Adenylate Cyclase - Olfactive Type antibody
Anti-Adenylyl Cyclase 3 antibody
Anti-Ac3 antibody
Anti-ADCY3 antibody
Anti-KIAA0511 antibody

Information sourced from Uniprot.org

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