Anti-ACTN2 antibody (C-Term) (STJ98460)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
ImmunogenPurified recombinant human Actinin-Alpha 2 (C-terminus) protein fragments expressed in E.coli.
General Information
| Short Description | Mouse monoclonal anti-Alpha-actinin-2 (C-Term) for use in WB and IF in Human, Rat, Cow, Chicken, Dog, Pig and Zebrafish samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF |
| Host | Mouse |
| Reactivity | Human/Rat/Cow/Chicken/Dog/Pig/Zebrafish |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity purification |
| Dilution Range | WB 1:1000-1:2000IF 1:100-1:500 |
| Formulation | Liquid in 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) , 0.2% Sodium Azide and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACTN2 |
| Gene ID | 88 |
| Uniprot ID | ACTN2_HUMAN |
| Immunogen | Purified recombinant human Actinin-Alpha 2 (C-terminus) protein fragments expressed in E.coli. |
| Immunogen Region | C-Term |
| Specificity | Actinin-Alpha 2 Monoclonal Antibody detects endogenous levels of Actinin-Alpha 2 protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated by FBXL22, leading to proteasomal degradation. |
| Function | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Protein Name | Alpha-Actinin-2Alpha-Actinin Skeletal Muscle Isoform 2F-Actin Cross-Linking Protein |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-373753Reactome: R-HSA-390522Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | CytoplasmMyofibrilSarcomereZ LineColocalizes With Myoz1 And Flnc At The Z-Lines Of Skeletal Muscle |
| Alternative Antibody Names | Anti-Alpha-Actinin-2 antibodyAnti-Alpha-Actinin Skeletal Muscle Isoform 2 antibodyAnti-F-Actin Cross-Linking Protein antibodyAnti-ACTN2 antibody |
Information sourced from Uniprot.org