| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Acetyl-Exportin-1-Lys568 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
XPO1 |
| Gene ID: |
7514 |
| Uniprot ID: |
XPO1_HUMAN |
| Specificity: |
Acetyl-CRM1 (K568) Polyclonal Antibody detects endogenous levels of CRM1 protein only when acetylation at K568. |
| Immunogen: |
Synthesized acetyl-peptide derived from the Internal region of human CRM1 around the acetylation site of K568. |
| Function | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. |
| Protein Name | Exportin-1Exp1Chromosome Region Maintenance 1 Protein Homolog |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-165054Reactome: R-HSA-168333Reactome: R-HSA-2173788Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-3769402Reactome: R-HSA-450520Reactome: R-HSA-5663220Reactome: R-HSA-5687128Reactome: R-HSA-68877Reactome: R-HSA-69273Reactome: R-HSA-9634638Reactome: R-HSA-9648025Reactome: R-HSA-9707616Reactome: R-HSA-9768919 |
| Cellular Localisation | CytoplasmNucleusNucleoplasmCajal BodyNucleolusLocated In The NucleoplasmCajal Bodies And NucleoliShuttles Between The Nucleus/Nucleolus And The Cytoplasm |
| Alternative Antibody Names | Anti-Exportin-1 antibodyAnti-Exp1 antibodyAnti-Chromosome Region Maintenance 1 Protein Homolog antibodyAnti-XPO1 antibodyAnti-CRM1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
