Anti-Acetyl-FOXO1-K262/K265/K274 antibody (STJ119528)

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Host: Rabbit
Applications: WB
Reactivity: Human
Short Description: Rabbit polyclonal primary antibody against FOXO1.
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification: Affinity purification
Storage Instruction: Store at-20°C. Avoid freeze/thaw cycles.
Isotype: IgG
Dilution Range: WB: 1:500-1:2000
Gene ID: 2308
Gene Symbol: FOXO1
Immunogen: A synthetic acetylated peptide around K262/K265/K274 of human FOXO1.
Background This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
Tissue Specificity Ubiquitous.
Database Links Reactome: R-HSA-198693
Cellular Localisation Cytoplasm
Shuttles Between The Cytoplasm And Nucleus
Largely Nuclear In Unstimulated Cells
In Osteoblasts
Colocalizes With Atf4 And Runx2 In The Nucleus
Serum Deprivation Increases Localization To The Nucleus
Leading To Activate Expression Of Sox9 And Subsequent Chondrogenesis
Insulin-Induced Phosphorylation At Ser-256 By Pkb/Akt1 Leads
Via Stimulation Of Thr-24 Phosphorylation
To Binding Of 14-3-3 Proteins And Nuclear Export To The Cytoplasm Where It Is Degraded By The Ubiquitin-Proteosomal Pathway
Phosphorylation At Ser-249 By Cdk1 Disrupts Binding Of 14-3-3 Proteins And Promotes Nuclear Accumulation
Phosphorylation By Nlk Results In Nuclear Export
Translocates To The Nucleus Upon Oxidative Stress-Induced Phosphorylation At Ser-212 By Stk4/Mst1
Sgk1-Mediated Phosphorylation Also Results In Nuclear Translocation
Retained In The Nucleus Under Stress Stimuli Including Oxidative Stress
Nutrient Deprivation Or Nitric Oxide
Retained In The Nucleus On Methylation
Protein Name Forkhead Box Protein O1
Forkhead Box Protein O1a
Forkhead In Rhabdomyosarcoma
Alternative Names Anti-Forkhead Box Protein O1 antibody
Anti-Forkhead Box Protein O1a antibody
Anti-Forkhead In Rhabdomyosarcoma antibody
Anti-FOXO1 antibody
Anti-FKHR antibody
Anti-FOXO1A antibody

Information sourced from

6 months standard