• Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using CBP (Acetyl-Lys1535) Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Acetyl-CBP (K1535) Polyclonal Antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000

Anti-Acetyl-CREBBP-K1535 antibody (1480-1550 aa) (STJ90134)

SKU:
STJ90134

Current Stock:
Host: Rabbit
Applications: WB, IHC-P, ELISA
Reactivity: Human, Mouse, Rat
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody anti-Acetyl CREB-binding protein K1535 (1480-1550 aa) is suitable for use in Western Blot, Immunohistochemistry and ELISA.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
Concentration: 1 mg/ml
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Gene Symbol: CREBBP
Gene ID: 1387
Uniprot ID: CBP_HUMAN
Immunogen Region: 1480-1550 aa
Specificity: Acetyl-CBP (K1535) polyclonal antibody detects endogenous levels of CBP protein only when acetylated at K1535.
Immunogen: Synthesized peptide derived from human CBP around the acetylation site of K1535
Function Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA.acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region. Acetylates DDX21, thereby inhibiting DDX21 helicase activity. Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway.
Protein Name Creb-Binding Protein
Histone Lysine Acetyltransferase Crebbp
Protein-Lysine Acetyltransferase Crebbp
Database Links Reactome: R-HSA-1234158
Reactome: R-HSA-1368082
Reactome: R-HSA-1368108
Reactome: R-HSA-1912408
Reactome: R-HSA-1989781
Reactome: R-HSA-201722
Reactome: R-HSA-210744
Reactome: R-HSA-2122947
Reactome: R-HSA-2151201
Reactome: R-HSA-2426168
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-3134973
Reactome: R-HSA-3214847
Reactome: R-HSA-3371568
Reactome: R-HSA-350054
Reactome: R-HSA-381340
Reactome: R-HSA-3899300
Reactome: R-HSA-400206
Reactome: R-HSA-400253
Reactome: R-HSA-5617472
Reactome: R-HSA-5621575
Reactome: R-HSA-6803204
Reactome: R-HSA-8866907
Reactome: R-HSA-8939246
Reactome: R-HSA-8941856
Reactome: R-HSA-9013508
Reactome: R-HSA-9013695
Reactome: R-HSA-9018519
Reactome: R-HSA-918233
Reactome: R-HSA-933541
Reactome: R-HSA-9614657
Reactome: R-HSA-9617629
Cellular Localisation Cytoplasm
Nucleus
Recruited To Nuclear Bodies By Ss18l1/Crest
In The Presence Of Alx1 Relocalizes From The Cytoplasm To The Nucleus
Alternative Antibody Names Anti-Creb-Binding Protein antibody
Anti-Histone Lysine Acetyltransferase Crebbp antibody
Anti-Protein-Lysine Acetyltransferase Crebbp antibody
Anti-CREBBP antibody
Anti-CBP antibody

Information sourced from Uniprot.org

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