• Immunohistochemistry of paraffin-embedded rat bone marrow using Aggrecan rabbit monoclonal antibody (STJ11101391) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry of paraffin-embedded mouse bone marrow using Aggrecan rabbit monoclonal antibody (STJ11101391) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.

Anti-ACAN antibody [ARC0678] (STJ11101391)

SKU:
STJ11101391

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Host: Rabbit
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit monoclonal antibody anti-Aggrecan is suitable for use in Western Blot and Immunohistochemistry.
Clonality: Monoclonal
Clone ID: ARC0678
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS containing 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC 1:50-1:200
Storage Instruction: Store in a freezer at-20°C and avoid freeze-thaw cycles.
Gene Symbol: ACAN
Gene ID: 176
Uniprot ID: PGCA_HUMAN
Immunogen: A synthesized peptide derived from human Aggrecan
Tissue Specificity Restricted to cartilages.
Post Translational Modifications Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.
Function This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
Protein Name Aggrecan Core Protein
Cartilage-Specific Proteoglycan Core Protein
Cspcp
Chondroitin Sulfate Proteoglycan Core Protein 1
Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-2022854
Reactome: R-HSA-2022857
Reactome: R-HSA-3000178
Reactome: R-HSA-3656225
Reactome: R-HSA-3656243
Reactome: R-HSA-3656244
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Antibody Names Anti-Aggrecan Core Protein antibody
Anti-Cartilage-Specific Proteoglycan Core Protein antibody
Anti-Cspcp antibody
Anti-Chondroitin Sulfate Proteoglycan Core Protein 1 antibody
Anti-Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2 antibody
Anti-ACAN antibody
Anti-AGC1 antibody
Anti-CSPG1 antibody
Anti-MSK16 antibody

Information sourced from Uniprot.org

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