Anti-ABRAXAS1-antibody (aa350-400) {Biotin} (STJ500023)

SKU:
STJ500023

Current Stock:
Host: Rabbit
Applications: ELISA, IP, WB
Reactivity: Human, Monkey
Short Description: Rabbit polyclonal antibody anti-ABRAXAS1 is suitable for use in ELISA, Immunoprecipitation and Western Blot.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Formulation: Tris/glycine buffer at pH 7.4 containing 0.02% sodium azide as preservative, cryo-protective agents, 0.5% stabilizing protein BSA and 30% glycerol.
Purification: Affinity Purified
Concentration: 0.52-0.63 µg/µl in antibody stabilization buffer
Dilution Range: DB-1:10, 000
ELISA-1:10, 000
IP-1:200
WB-1:500
Storage Instruction: Store at-20°C. Avoid freeze/thaw cycles.
Gene Symbol: ABRAXAS1
Gene ID: 84142
Uniprot ID: ABRX1_HUMAN
Immunogen Region: 350-400
Immunogen: Synthetic peptide taken within amino acid region 350-400 on human BRCA1-A complex subunit Abraxas protein.
Post Translational Modifications Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Ionizing radiation promotes rapid phosphorylation at Ser-404 and Ser-406 by ATM.this promotes recruitment of BRCA1 to sites of DNA damage.
Function Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Protein Name Brca1-A Complex Subunit Abraxas 1
Coiled-Coil Domain-Containing Protein 98
Protein Fam175a
Database Links Reactome: R-HSA-5689901
Reactome: R-HSA-5693565
Reactome: R-HSA-5693571
Reactome: R-HSA-5693607
Reactome: R-HSA-69473
Cellular Localisation Nucleus
Localizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs)
Alternative Antibody Names Anti-Brca1-A Complex Subunit Abraxas 1 antibody
Anti-Coiled-Coil Domain-Containing Protein 98 antibody
Anti-Protein Fam175a antibody
Anti-ABRAXAS1 antibody
Anti-ABRA1 antibody
Anti-CCDC98 antibody
Anti-FAM175A antibody
Anti-UNQ496 antibody
Anti-PRO1013 antibody

Information sourced from Uniprot.org

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