Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human, Rat |
Note: |
FOR RESEARCH USE ONLY (RUO). |
Short Description: |
Rabbit polyclonal antibody anti-ABHD12 is suitable for use in Western Blot. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS containing 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000 |
Storage Instruction: |
Store in a freezer at-20°C and avoid freeze-thaw cycles. |
Gene Symbol: |
ABHD12 |
Gene ID: |
26090 |
Uniprot ID: |
ABD12_HUMAN |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 110-250 of human ABHD12 (NP_056415.1). |
Post Translational Modifications | Glycosylated.glycosylation is required for optimal activity. |
Function | Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine.oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates.substrate specificity is likely due to improved catalysis and not improved substrate binding. |
Protein Name | Lysophosphatidylserine Lipase Abhd122-Arachidonoylglycerol Hydrolase Abhd12Abhydrolase Domain-Containing Protein 12Habhd12Monoacylglycerol Lipase Abhd12Oxidized Phosphatidylserine Lipase Abhd12 |
Database Links | Reactome: R-HSA-426048 |
Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
Alternative Antibody Names | Anti-Lysophosphatidylserine Lipase Abhd12 antibodyAnti-2-Arachidonoylglycerol Hydrolase Abhd12 antibodyAnti-Abhydrolase Domain-Containing Protein 12 antibodyAnti-Habhd12 antibodyAnti-Monoacylglycerol Lipase Abhd12 antibodyAnti-Oxidized Phosphatidylserine Lipase Abhd12 antibodyAnti-ABHD12 antibodyAnti-C20orf22 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance