||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-ABHD12 is suitable for use in Western Blot.
||PBS containing 0.02% Sodium Azide, 50% Glycerol, pH7.3.
||Store in a freezer at-20°C and avoid freeze-thaw cycles.
||Recombinant fusion protein containing a sequence corresponding to amino acids 110-250 of human ABHD12 (NP_056415.1).
| Post Translational Modifications || Glycosylated.glycosylation is required for optimal activity. |
| Function || Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine.oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates.substrate specificity is likely due to improved catalysis and not improved substrate binding. |
| Protein Name || Lysophosphatidylserine Lipase Abhd122-Arachidonoylglycerol Hydrolase Abhd12Abhydrolase Domain-Containing Protein 12Habhd12Monoacylglycerol Lipase Abhd12Oxidized Phosphatidylserine Lipase Abhd12 |
| Database Links || Reactome: R-HSA-426048 |
| Cellular Localisation || Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names || Anti-Lysophosphatidylserine Lipase Abhd12 antibodyAnti-2-Arachidonoylglycerol Hydrolase Abhd12 antibodyAnti-Abhydrolase Domain-Containing Protein 12 antibodyAnti-Habhd12 antibodyAnti-Monoacylglycerol Lipase Abhd12 antibodyAnti-Oxidized Phosphatidylserine Lipase Abhd12 antibodyAnti-ABHD12 antibodyAnti-C20orf22 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance