| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATP-binding cassette sub-family D member 2 (310-390 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABCD2 |
| Gene ID: |
225 |
| Uniprot ID: |
ABCD2_HUMAN |
| Immunogen Region: |
310-390 aa |
| Specificity: |
ABCD2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 310-390 |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation. |
| Protein Name | Atp-Binding Cassette Sub-Family D Member 2Adrenoleukodystrophy-Like 1Adrenoleukodystrophy-Related ProteinHaldr |
| Database Links | Reactome: R-HSA-1369062Reactome: R-HSA-9603798 |
| Cellular Localisation | Peroxisome MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family D Member 2 antibodyAnti-Adrenoleukodystrophy-Like 1 antibodyAnti-Adrenoleukodystrophy-Related Protein antibodyAnti-Haldr antibodyAnti-ABCD2 antibodyAnti-ALD1 antibodyAnti-ALDL1 antibodyAnti-ALDR antibodyAnti-ALDRP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
